Research Peptide Comparison
PT-141 (Bremelanotide) and Tesamorelin offer researchers a striking mechanistic contrast, as both are synthetic peptides with defined receptor targets yet they engage wholly separate neuroendocrine circuits. PT-141 is a cyclic heptapeptide melanocortin receptor agonist — with activity principally characterised at MC3R and MC4R. Tesamorelin acts at a structurally unrelated receptor class, the GHRH-R on anterior pituitary somatotrophs, initiating an entirely distinct intracellular cAMP-mediated signalling cascade that culminates in growth hormone release.
PT-141 (Bremelanotide) is a cyclic heptapeptide melanocortin-receptor agonist with primary activity at the MC3R and MC4R subtypes, exerting its effects through central nervous system signalling rather than peripheral vascular pathways. This mechanism has placed it at the centre of research into central arousal circuits, sexual health pharmacology and melanocortin-system pharmacology more broadly.
Compared to Tesamorelin 5mg, PT-141 10mg is priced at £16.99 with 99%+ verified purity. Its CAS registry number is 189691-06-3. It has a molecular weight of 1025.18 g/mol.
PT-141 10mg is available in single size and ships with a full Certificate of Analysis from Janoshik Analytical. At £23.00 less than Tesamorelin 5mg, it is the more affordable option in this comparison.
Tesamorelin is a synthetic analog of human growth hormone-releasing hormone (GHRH) modified at the N-terminus to confer resistance to enzymatic degradation and prolong receptor engagement. It is one of the more thoroughly characterised GHRH analogs in metabolic research, with literature focused on visceral adipose tissue reduction, IGF-1 dynamics and lipid-profile modulation.
Compared to PT-141 10mg, Tesamorelin 5mg is priced at £39.99 with 99%+ verified purity. Its CAS registry number is 218949-48-5. It has a molecular weight of 5135.90 g/mol.
Tesamorelin 5mg is available in 5mg, 10mg and ships with a full Certificate of Analysis from Janoshik Analytical. It is priced £23.00 higher than PT-141 10mg.
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