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Research Peptides
TB-500
MW: 4963.50 g/molCAS: 77591-33-4
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A broad portfolio of characterised peptides for tissue repair, growth hormone axis, and reproductive signalling research.
Research Peptides
Research Peptides
Research Peptides
Research Peptides
Research Peptides
Research Peptides
Research Peptides
Research Peptides
Research Peptides
Research Peptides
Research Peptides
Research Peptides
Research Peptides
Peptides are uniquely positioned as research tools because their defined sequences confer predictable receptor specificity, enabling investigators to probe discrete signalling pathways with high selectivity. This category encompasses compounds that span several major biological axes: the growth hormone secretagogue system (Ipamorelin, CJC-1295, Tesamorelin), tissue repair and cytoprotection pathways (BPC-157, TB-500/Thymosin Beta-4), reproductive neuroendocrine signalling (Kisspeptin, HCG), melanocortin receptor pharmacology (PT-141), mitochondrial-derived peptide biology (MOTS-c), innate immune modulation (KPV Alpha), and ESRR agonism (SLU-PP-332). The breadth of mechanisms represented makes this collection useful for researchers working across endocrinology, immunology, regenerative biology, and cellular metabolism.
BPC-157 is a pentadecapeptide fragment derived from gastric juice protein that has attracted significant research interest for its apparent cytoprotective effects across multiple tissue types in animal models, with proposed involvement of nitric oxide and growth factor signalling pathways. TB-500, based on the actin-sequestering domain of Thymosin Beta-4, is studied for its role in cytoskeletal dynamics and cell migration. MOTS-c is a mitochondrial-encoded peptide that activates AMPK and the AICAR pathway, situating it within the emerging field of mitochondrial hormones (mitokines). SLU-PP-332 is a synthetic agonist for the oestrogen-related receptors ERRα/β/γ — nuclear receptors that regulate mitochondrial biogenesis and oxidative metabolism — making it a valuable tool for researchers studying transcriptional control of energy homeostasis.
BPC-157 & TB-500: Joint, Tendon and Spinal Research
9 min readUnderstanding Certificates of Analysis (COA) for Research Peptides
6 min readBPC-157: A Comprehensive Research Guide
7 min readPeptide Stability & Degradation: What Researchers Need to Know
6 min readUnderstanding HPLC and Mass Spectrometry Results for Peptides
7 min readResearch Peptides for Beginners: A Starter Primer
8 min readAre Research Peptides Legal in the UK? A Plain-English Overview
6 min readThird-Party Peptide Testing: How Independent COAs Verify Purity
7 min readPreclinical studies have proposed multiple mechanisms for BPC-157's observed cytoprotective effects, including upregulation of nitric oxide synthase (eNOS) activity and downstream NO-mediated vasodilation, interaction with the growth hormone receptor and EGF receptor signalling, and modulation of FAK-paxillin pathway components involved in cell survival and migration. Research has also noted effects on the JAK-STAT pathway. Because BPC-157 acts across several systems simultaneously, researchers often use it as a tool to study pathway redundancy in tissue protection models rather than attributing effects to a single mechanism.
CJC-1295 is a growth hormone-releasing hormone (GHRH) analogue that binds the GHRH receptor on pituitary somatotroph cells to stimulate GH gene transcription and secretion. Ipamorelin is a selective growth hormone secretagogue receptor (GHSR-1a) agonist that triggers GH release through a ghrelin-mimetic mechanism independently of GHRH. Used together in cell or tissue culture models, they allow researchers to study additive pituitary stimulation through two distinct receptor systems, and to compare GHRH-dependent versus GHSR-dependent downstream signalling (cAMP/PKA versus PLC/IP3 cascades) in the same experimental context.
Kisspeptin (encoded by the KISS1 gene) and its receptor KISS1R (GPR54) form a critical regulatory node in the hypothalamic-pituitary-gonadal (HPG) axis. Kisspeptin neurons in the arcuate and anteroventral periventricular nuclei integrate metabolic, photoperiodic, and steroidal signals to control GnRH pulsatility, which in turn drives LH and FSH secretion. Researchers use Kisspeptin in in vitro and ex vivo models to study the molecular logic of neuroendocrine pulse generation, the mechanisms of steroid feedback on the HPG axis, and the metabolic gating of reproductive function — topics relevant to fertility biology and neuroendocrine physiology.
MOTS-c (mitochondrial open reading frame of the 12S rRNA type-c) is a small peptide encoded within the mitochondrial genome — specifically within the 12S rRNA gene — making it one of a small class of mitochondrial-derived peptides (MDPs). Its biological interest lies in its ability to translocate to the nucleus under metabolic stress, where it activates AMPK-dependent pathways and drives the expression of genes involved in glucose uptake, folate metabolism, and antioxidant defence. Researchers studying inter-organelle communication, mitohormesis, and the role of mitochondrial-encoded signals in systemic energy regulation use MOTS-c as a molecular probe for this emerging axis.
All products sold by Neovia Peptides are strictly for in-vitro research and laboratory use only. Not intended for human or veterinary use, food additives, drugs, or cosmetics. By purchasing from this website, you agree that you understand and accept these terms.