Research Peptide Comparison
MOTS-c is a 16-amino acid peptide encoded within the mitochondrial 12S rRNA gene that functions as an endogenous metabolic regulator, activating AMPK signalling cascades and influencing nuclear gene expression involved in glucose homeostasis, mitochondrial biogenesis, and cellular stress adaptation. PT-141 (Bremelanotide) is a cyclic heptapeptide melanocortin receptor agonist derived from Melanotan II, with preclinical and early translational research focusing predominantly on its activity at MC3R and MC4R subtypes within central nervous system pathways. These two peptides represent markedly divergent research territories — one rooted in mitochondrial genomics and systemic metabolic regulation, the other in melanocortin neuropeptide pharmacology.
MOTS-c is a mitochondrially-encoded 16-amino-acid peptide that translocates to the nucleus under metabolic stress and engages the AMPK pathway to coordinate cytoprotective and substrate-utilisation responses. It is a primary subject of mitokine research and of investigations into how mitochondrial-derived signals shape aging, insulin sensitivity, and exercise adaptation.
Compared to PT-141 10mg, MOTS-c 40mg is priced at £65.00 with 99%+ verified purity. Its CAS registry number is 1627580-64-6. It has a molecular weight of 2174.68 g/mol.
MOTS-c 40mg is available in 10mg, 40mg and ships with a full Certificate of Analysis from Janoshik Analytical. It is priced £48.01 higher than PT-141 10mg.
PT-141 (Bremelanotide) is a cyclic heptapeptide melanocortin-receptor agonist with primary activity at the MC3R and MC4R subtypes, exerting its effects through central nervous system signalling rather than peripheral vascular pathways. This mechanism has placed it at the centre of research into central arousal circuits, sexual health pharmacology and melanocortin-system pharmacology more broadly.
Compared to MOTS-c 40mg, PT-141 10mg is priced at £16.99 with 99%+ verified purity. Its CAS registry number is 189691-06-3. It has a molecular weight of 1025.18 g/mol.
PT-141 10mg is available in single size and ships with a full Certificate of Analysis from Janoshik Analytical. At £48.01 less than MOTS-c 40mg, it is the more affordable option in this comparison.
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