Research Peptide Comparison
MOTS-c is a mitochondrial-derived peptide that activates AMPK signalling and has been investigated in preclinical models for its role in regulating metabolic flexibility, insulin sensitivity pathways, and the mitochondrial-to-nuclear retrograde communication axis. SLU-PP-332 is a small-molecule agonist of the oestrogen-related receptors ERRα and ERRγ, transcription factors that govern mitochondrial biogenesis, oxidative phosphorylation gene networks, and skeletal muscle fibre-type adaptation, leading to its characterisation in research literature as an exercise mimetic. Comparing these two compounds allows researchers to interrogate overlapping but mechanistically distinct nodes of mitochondrial metabolic programming — one via a peptide messenger originating within the mitochondrial genome, the other via direct nuclear receptor activation.
MOTS-c is a mitochondrially-encoded 16-amino-acid peptide that translocates to the nucleus under metabolic stress and engages the AMPK pathway to coordinate cytoprotective and substrate-utilisation responses. It is a primary subject of mitokine research and of investigations into how mitochondrial-derived signals shape aging, insulin sensitivity, and exercise adaptation.
Compared to SLU-PP-332 5mg, MOTS-c 40mg is priced at £65.00 with 99%+ verified purity. Its CAS registry number is 1627580-64-6. It has a molecular weight of 2174.68 g/mol.
MOTS-c 40mg is available in 10mg, 40mg and ships with a full Certificate of Analysis from Janoshik Analytical. It is priced £25.01 higher than SLU-PP-332 5mg.
SLU-PP-332 is a small-molecule selective pan-agonist of the oestrogen-related receptors (ERRα, ERRβ and ERRγ), orphan nuclear receptors that regulate mitochondrial biogenesis, oxidative metabolism and skeletal muscle endurance programmes. By engaging all three ERR subtypes it has emerged as a leading exercise-mimetic research tool for interrogating metabolic adaptation and oxidative capacity.
Compared to MOTS-c 40mg, SLU-PP-332 5mg is priced at £39.99 with 99%+ verified purity. It has a molecular weight of 438.52 g/mol.
SLU-PP-332 5mg is available in single size and ships with a full Certificate of Analysis from Janoshik Analytical. At £25.01 less than MOTS-c 40mg, it is the more affordable option in this comparison.
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