Research Peptide Comparison
KPV Alpha and PT-141 both derive their pharmacological relevance from the melanocortin system, yet they engage this system at distinctly different points and have been studied in markedly different biological contexts. PT-141 (Bremelanotide) is a cyclic melanocortin receptor agonist with high affinity for MC3R and MC4R, receptors located predominantly in the central nervous system. KPV Alpha, the C-terminal tripeptide fragment of α-MSH, interacts preferentially with peripheral melanocortin receptors and has been studied in the context of intestinal epithelial inflammation and mucosal immune modulation.
KPV is the C-terminal Lysine-Proline-Valine tripeptide of α-melanocyte-stimulating hormone (α-MSH) and retains a substantial portion of the parent peptide's anti-inflammatory activity in a markedly smaller scaffold. It modulates NF-κB signalling and downstream pro-inflammatory cytokine output, making it a frequent probe in mucosal inflammation, epithelial barrier and immune-cell research.
Compared to PT-141 10mg, KPV Alpha 10mg is priced at £29.99 with 99%+ verified purity. Its CAS registry number is 67727-97-3. It has a molecular weight of 357.45 g/mol.
KPV Alpha 10mg is available in single size and ships with a full Certificate of Analysis from Janoshik Analytical. It is priced £13.00 higher than PT-141 10mg.
PT-141 (Bremelanotide) is a cyclic heptapeptide melanocortin-receptor agonist with primary activity at the MC3R and MC4R subtypes, exerting its effects through central nervous system signalling rather than peripheral vascular pathways. This mechanism has placed it at the centre of research into central arousal circuits, sexual health pharmacology and melanocortin-system pharmacology more broadly.
Compared to KPV Alpha 10mg, PT-141 10mg is priced at £16.99 with 99%+ verified purity. Its CAS registry number is 189691-06-3. It has a molecular weight of 1025.18 g/mol.
PT-141 10mg is available in single size and ships with a full Certificate of Analysis from Janoshik Analytical. At £13.00 less than KPV Alpha 10mg, it is the more affordable option in this comparison.
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