Research Peptide Comparison
Ipamorelin and Tesamorelin represent two pharmacologically distinct approaches to modulating the growth hormone axis. Ipamorelin is a selective pentapeptide ghrelin receptor agonist (GHS-R1a) that stimulates pulsatile GH release from somatotroph cells with a notably clean selectivity profile, exhibiting minimal influence on cortisol or prolactin secretion in preclinical models. Tesamorelin, by contrast, is a stabilised synthetic analogue of endogenous growth hormone-releasing hormone (GHRH) that acts directly at pituitary GHRH receptors to amplify physiological GH secretion. Researchers investigating GH-axis modulation, somatotroph signalling, and the comparative downstream IGF-1 profiles of GHS-R versus GHRH-R pathway activation will find this pairing a particularly informative reference point.
Ipamorelin is a pentapeptide growth hormone-releasing peptide (GHRP) and selective agonist of the ghrelin (GHS-R1a) receptor. It is widely cited for its capacity to stimulate pituitary GH release without the cortisol, prolactin or aldosterone elevations associated with earlier GHRPs, making it a clean reference ligand in somatotropic and receptor-selectivity research.
Compared to Tesamorelin 5mg, Ipamorelin 5mg is priced at £19.99 with 99%+ verified purity. Its CAS registry number is 170851-70-4. It has a molecular weight of 711.85 g/mol.
Ipamorelin 5mg is available in 5mg, 10mg and ships with a full Certificate of Analysis from Janoshik Analytical. At £20.00 less than Tesamorelin 5mg, it is the more affordable option in this comparison.
Tesamorelin is a synthetic analog of human growth hormone-releasing hormone (GHRH) modified at the N-terminus to confer resistance to enzymatic degradation and prolong receptor engagement. It is one of the more thoroughly characterised GHRH analogs in metabolic research, with literature focused on visceral adipose tissue reduction, IGF-1 dynamics and lipid-profile modulation.
Compared to Ipamorelin 5mg, Tesamorelin 5mg is priced at £39.99 with 99%+ verified purity. Its CAS registry number is 218949-48-5. It has a molecular weight of 5135.90 g/mol.
Tesamorelin 5mg is available in 5mg, 10mg and ships with a full Certificate of Analysis from Janoshik Analytical. It is priced £20.00 higher than Ipamorelin 5mg.
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