Research Peptide Comparison
Ipamorelin is a selective pentapeptide growth hormone secretagogue that binds the ghrelin receptor (GHS-R1a) with high specificity, stimulating pulsatile GH release without appreciably elevating cortisol or prolactin in preclinical models. MOTS-c is a 16-amino acid mitochondrial-derived peptide encoded within the 12S rRNA gene of mitochondrial DNA, notable for its activation of the AMPK pathway and regulation of nuclear gene expression linked to metabolic homeostasis. Researchers comparing these two compounds are typically investigating the intersection of somatotropic axis modulation and mitochondrial-nuclear communication, two mechanistically distinct but potentially complementary areas of metabolic research.
Ipamorelin is a pentapeptide growth hormone-releasing peptide (GHRP) and selective agonist of the ghrelin (GHS-R1a) receptor. It is widely cited for its capacity to stimulate pituitary GH release without the cortisol, prolactin or aldosterone elevations associated with earlier GHRPs, making it a clean reference ligand in somatotropic and receptor-selectivity research.
Compared to MOTS-c 40mg, Ipamorelin 5mg is priced at £19.99 with 99%+ verified purity. Its CAS registry number is 170851-70-4. It has a molecular weight of 711.85 g/mol.
Ipamorelin 5mg is available in 5mg, 10mg and ships with a full Certificate of Analysis from Janoshik Analytical. At £45.01 less than MOTS-c 40mg, it is the more affordable option in this comparison.
MOTS-c is a mitochondrially-encoded 16-amino-acid peptide that translocates to the nucleus under metabolic stress and engages the AMPK pathway to coordinate cytoprotective and substrate-utilisation responses. It is a primary subject of mitokine research and of investigations into how mitochondrial-derived signals shape aging, insulin sensitivity, and exercise adaptation.
Compared to Ipamorelin 5mg, MOTS-c 40mg is priced at £65.00 with 99%+ verified purity. Its CAS registry number is 1627580-64-6. It has a molecular weight of 2174.68 g/mol.
MOTS-c 40mg is available in 10mg, 40mg and ships with a full Certificate of Analysis from Janoshik Analytical. It is priced £45.01 higher than Ipamorelin 5mg.
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