Research Peptide Comparison
Human Chorionic Gonadotropin (hCG) and Kisspeptin both exert profound influence over the hypothalamic-pituitary-gonadal axis, yet they engage the reproductive endocrine system at structurally distinct levels. hCG is a glycoprotein hormone that acts as a functional analogue of luteinising hormone (LH), directly binding LH/hCG receptors on gonadal cells to stimulate steroidogenesis. Kisspeptin operates considerably upstream, acting on GPR54 receptors on hypothalamic GnRH neurons to drive GnRH pulsatility and thus indirectly regulate both LH and FSH secretion. The contrast between a direct gonadotropin-mimetic and an upstream neuroendocrine gatekeeper offers researchers a powerful dual-tool approach to mapping the hierarchical architecture of reproductive hormonal control.
Human Chorionic Gonadotropin (hCG) is a placental glycoprotein hormone that binds the luteinising hormone (LH) receptor, driving downstream steroidogenic signalling in gonadal tissue. Its near-identical receptor affinity to endogenous LH makes it a standard probe in hypothalamic-pituitary-gonadal (HPG) axis investigation, reproductive endocrinology, and Leydig and theca cell stimulation studies.
Compared to Kisspeptin 5mg, HCG 5000iu is priced at £23.99 with 99%+ verified purity. Its CAS registry number is 9002-61-3. It has a molecular weight of 36.7 kDa.
HCG 5000iu is available in single size and ships with a full Certificate of Analysis from Janoshik Analytical. It is priced £5.00 higher than Kisspeptin 5mg.
Kisspeptin-10, the C-terminal decapeptide fragment of metastin, is the minimal active sequence at the KISS1R (GPR54) receptor and a primary upstream regulator of GnRH neuron firing. By controlling pulsatile GnRH release, it sits at the apex of the hypothalamic-pituitary-gonadal (HPG) axis and has become a central tool in fertility, puberty-onset and reproductive endocrinology investigation.
Compared to HCG 5000iu, Kisspeptin 5mg is priced at £18.99 with 99%+ verified purity. Its CAS registry number is 374675-21-5. It has a molecular weight of 1302.48 g/mol.
Kisspeptin 5mg is available in 5mg, 10mg and ships with a full Certificate of Analysis from Janoshik Analytical. At £5.00 less than HCG 5000iu, it is the more affordable option in this comparison.
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