5-Amino-1MQ 10mg

5-Amino-1MQ (5-amino-1-methylquinolinium iodide) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that consumes methyl groups and depletes nicotinamide pools. By blocking NNMT, 5-Amino-1MQ raises intracellular NAD+ and SAM availability and has been shown in preclinical models to drive adipocyte size reduction and preserve skeletal muscle integrity. This 10mg vial is positioned as a pilot unit for early mechanism and dose-response research.

Supplied as high-purity solid for reconstitution in an appropriate aqueous or DMSO-compatible vehicle. The 10mg format is suited to short adipocyte and myoblast cell-culture series, target-engagement screening, and bench validation prior to in vivo scale-up.

Research Applications • NNMT enzyme inhibition and methyl-donor flux assays • Adipocyte hypertrophy, lipolysis, and white-adipose-browning models • Skeletal muscle stem-cell and sarcopenia research • NAD+ pool restoration as an alternative to precursor supplementation

Specification • Identity: 5-Amino-1MQ / 5-amino-1-methylquinolinium iodide (CAS 19015-72-2) • Molecular weight: 286.11 g/mol • Purity: 99%+ verified by HPLC and Mass Spectrometry • Format: lyophilised solid — reconstitute with sterile water, saline, or DMSO depending on assay • Storage: store sealed solid at -20°C protected from light and moisture; once reconstituted, aliquot and refrigerate at 2-8°C; minimise freeze-thaw cycles

For research use only — not for human consumption.